Diagnosis of Cancer after a Diagnosis of Tuberculosis

Several studies have found an association between tuberculosis (TB) and lung cancer - though it's still not certain if TB is a cause of lung cancer. A new study set out to see if TB is associated with an increased risk of other cancers as well.

Researchers looked at people who were diagnosed with TB in Taiwan and compared these people to those without tuberculosis. Overall, those who were diagnosed with TB were almost twice as likely to be diagnosed with cancer. The results were broken down as follows:

• For men in the first year after a TB diagnosis there were increased rates of head and neck cancer, esophageal cancer, colorectal cancer, liver cancer, lung cancer, melanoma, and Hodgkin's disease.
• For men after the first year there were increased rates of liver, biliary, lung and bladder cancers.
• For women, there were increased rates of leukemia, esophageal cancer, and lung cancer in the first year.
• For women following the first year after a diagnosis of TB, there was an increased rate of leukemia.

Does this mean TB causes cancer?

There is some evidence that supports this. Chronic inflammation leading to DNA damage may play a role in the development of lung cancer. But there are many other variables. It's important to note that association doesn't mean causation. People eat more ice cream in the summer and there are more people who drown in the summer. But this doesn't mean that ice cream causes drowning.

What should be the take home message be?

For those who have been diagnosed with TB, doctors should be aware of this correlation, especially if patients have symptoms suggestive of cancer. For those with TB, having this awareness is a reminder to be aware of the signs and symptoms of cancer, and to see your doctor if you have any concern.

Read more about the connection between lung cancer and TB, how lung cancer may be misdiagnosed as TB, and how TB may affect those living with cancer:

Photo: A.D.A.M. Medical Encycopedia

_Source:

_{Kuo, S. et al. Association between tuberculosis infections and non-pulmonary malignancies: a nationwide population-based study. British Journal of Cancer. 2013 May 7. (Epub ahead of print).}

Source: http://lungcancer.about.com/b/2013/06/29/diagnosis-of-cancer-after-a-diagnosis-of-tuberculosis.htm

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Presidential palace in Afghanistan attacked

KABUL, Afghanistan (AP) ? The Taliban say they have hit one of the most secure areas of the Afghan capital with a suicide attack, as a series of explosion rocked the gate leading into the presidential palace.

Smoke rose from the eastern gate of the palace early Tuesday after more than a half dozen explosions and at least 45 minutes of on-and-off small arms fire.

The Taliban sent a quick text-message statement saying "we brought death to the enemy."

The palace is in a large fortified area of downtown Kabul that also includes the U.S. Embassy and the headquarters for the NATO-led coalition forces.

Reporters gathering for an event with President Hamid Karzai counted at least seven or eight explosions starting about 6:30 a.m.

Police had no immediate comment.

Source: http://news.yahoo.com/taliban-attack-presidential-palace-afghanistan-030026459.html

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'Mad Men's' Don Draper: Sexy, but so sad

TV

Anna Chan TODAY

24 minutes ago

Michael Yarish / AMC

Don Draper found himself surrounded by people, yet all alone and sad, in the ninth episode of the season, titled "Better Half."

It's been a long, sad season for Don Draper on "Mad Men." It seemed almost every episode featured at least one shot of the handsome ad man brooding -- and in some cases, even shedding a tear or two.

What's he got to cry about, you say? We hear you: He's a rich, very successful, good-looking guy with a gorgeous wife. As far as viewers can see, he's still got his health too. (At least, we think so. His liver hasn't started failing from all that drinking yet, right?) So why the long face, Don?

Turns out maybe we should cut the guy a little slack. Money and good looks can't buy happiness, after all. (Just a lot of other stuff that makes life a bit easier.)

Dumped
Nobody tells Don Draper what's what! Unless you're his neighbor/mistress, apparently. In the episode titled "Man With a Plan," the ad man does his own version of "50 Shades of Grey" and orders lover Sylvia to stay in her hotel room all day (although it felt more like days), even taking away her book at one point. By the end of that ordeal, she'd had an epiphany and dumped him. His response? Disbelief. Sad face. Begging. And later, more begging on the phone.

Who are you?
Daughter Sally delivered a knife to Don's -- and viewers' -- hearts this year. After the Draper residence is burgled while the adults are away and Sally was left behind to watch her little brothers, she explained to Don why she was duped into believing the thief -- a black woman -- was her grandma. "She said she knew you," Sally told her dad on the phone later. "I asked her everything I know and she had an answer for everything. Then I realized I don't know anything about you." Sad, ponderous face.

All by himself
Don's often surrounded by people, whether he's at the office, having a meal with clients or enjoying a little tryst with someone. When he hooked up with ex-wife Betty while visiting son Bobby at camp, he admitted that he'd missed her, hinting at how unhappy he is in his current marriage. "Why is sex the definition of being close to someone?" he asked. Her reply? "I don't know. But it is for me, it is for most people." Cue the sad face. And by the next morning, they were miles apart again. As Don headed into the diner for breakfast, he saw Betty sitting with her husband, Henry ... and Don shuffled off to sit alone.

Drowning
After smoking some hashish at a Hollywood party, Don started to hallucinate first the happy, then the sad. The vision of a pregnant Megan came to him first, then Dinkins, the soldier he met in the season premiere. Except now, the young man is missing an arm -- and is dead. "Dying doesn't make you whole," Dinkins told Don when asked why the deceased vet was still missing his appendage in the afterlife. "You should see what you look like." And what does the ad man look like? Depressed. And dead. Floating in a pool face-down dead. But fortunately for him, the dead part was a hallucination, but he really was drowning in the pool until Roger dove in and saved him.

Busted
When Don finally got caught cheating with Sylvia, it wasn't by who viewers -- or Don himself -- were probably expecting. It was Sally who walked in on the two lovebirds. This sent Don first into panic mode, which eventually morphed into depression. It became obvious two episodes later, when Don started out the penultimate episode of the season curled up in a fetal position on Sally's bed, and ended the hour the same way, realizing that his actions have cost him a relationship with his little girl.

What Sunday's finale holds for Don's happiness, you'll have to tune in and see at 10 p.m. on AMC.

Source: http://www.today.com/entertainment/mad-mens-don-draper-sexy-successful-so-sad-6C10367555

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Lilly once-weekly diabetes drug proves superior in late-stage trials

By Bill Berkrot

(Reuters) - A once-weekly drug for type 2 diabetes developed by Eli Lilly and Co worked better at controlling blood sugar than three other widely used medicines, according to data from late- stage clinical trials.

The data, presented on Saturday at the American Diabetes Association (ADA) meeting in Chicago, also showed that the Lilly shot helped patients lose twice as much weight as those taking Merck & Co's $4 billion-a-year drug, Januvia.

The findings from the trio of late-stage studies suggest the treatment known as dulaglutide could be an important new weapon in the fight against type 2 diabetes, whose rapid growth globally has become a crisis affecting more than 300 million people.

"This is a very promising, safe and efficacious agent for the treatment of diabetes," Dr Guillermo Umpierrez, one of the lead investigators of the dulaglutide Phase III trial program, said in an interview.

Diabetes is a disease in which the body does not produce enough insulin to control levels of blood sugar. It can lead to many serious health complications including heart problems, kidney disease and vision loss.

The results of the new studies showed that an injection of dulaglutide led to sustained reductions in blood sugar and helped more patients reach recommended target levels than those taking generic metformin, Byetta, a drug from Bristol-Myers Squibb Co, and Januvia, the studies showed. There were no reported cases of serious hypoglycemia, or dangerously low blood sugar.

Lilly plans to use data from the three trials as a major part of the application seeking U.S. approval for dulaglutide it expects to file later this year.

If approved, dulaglutide would become a direct rival of once-weekly Bydureon, sold by Bristol-Myers Squibb and AstraZeneca Plc, and Victoza from Danish drugmaker Novo Nordisk.

Like those medicines, dulaglutide belongs to a class of injected drugs known as GLP-1 receptor agonists that work by increasing the release of insulin after meals and by slowing absorption of food in the gastrointestinal tract.

Doctors are still likely to initially reach for oral drugs such as metformin for type 2 patients, but an injectable drug that needs to be taken only once a week could become an important treatment, researchers said, as diabetics often need two or three medicines to properly control blood glucose.

"I believe the use of GLP-1s will continue to increase and this new formulation of a once-a-week administration will be very attractive to patients and physicians," said Umpierrez, a professor of medicine at Emory University in Atlanta who presented data from one of the trials at the meeting.

SAFETY RISK?

While data from the three studies appears to show a comforting safety profile, dulaglutide will be under intense scrutiny from health regulators. The GLP-1 class, and the DPP-4 inhibitors to which Januvia belongs, have been associated with unconfirmed reports that they may cause serious inflammation of the pancreas and cell changes that can lead to cancer.

Two cases of pancreatic cancer reported among study participants were deemed highly unlikely to be connected to dulaglutide, the company and researchers said.

Lilly said there were similar rates of pancreatitis among patients taking comparator drugs or a placebo.

"There is no concern so far of pancreatitis or pancreatic tumors," Umpierrez said.

One of the studies dubbed Award-1, involving 978 patients over 52 weeks, tested dulaglutide against Byetta, a which is injected twice a day. Subjects in the study were already taking metformin and Takeda Pharmaceutical Co's Actos.

Adding dulaglutide to this mix helped 80 percent of patients reach target blood sugar levels - an A1c of 7 - compared with about 50 percent of those taking Byetta.

Dulaglutide and Byetta patients on average lost 3.3 pounds (1.5 kilograms), an attractive side benefit as obesity is a leading cause of type 2 diabetes.

In a separate 52-week study called Award-3, researchers tested dulaglutide against metformin - the most commonly used initial treatment for type 2 diabetes - in 807 patients earlier in their disease progression. They began the trial with an average A1c of 7.6 percent, above the ADA target of 7 percent.

People who took a 1.5 mg dose of the Lilly drug saw an average drop in their A1c of 0.8 percent, with 62 percent of patients getting to target blood sugar levels. That compared with a drop of 0.56 percent for metformin with 54 percent getting to goal.

Weight loss with dulaglutide was about 4.4 pounds (2 kg) and 3.3 pounds (1.5 kg) for metformin.

A third trial, dubbed Award-5, was a two-year study that tested dulaglutide against Januvia in more than 1,000 patients who were already taking metformin.

Patients who got dulaglutide had an average A1c reduction of 1.1 percent, with 60 percent of them achieving target levels, versus a reduction of 0.4 percent for Januvia with 30 percent getting to the ADA goal.

Average weight loss with the Lilly drug was 7 pounds (3.2 kg), while Januvia patients lost an average of 3.5 pounds (1.6 kg). The most common side effect reported in the three studies for dulaglutide was nausea, researchers said.

(Reporting by Bill Berkrot; editing by Julie Steenhuysen and Matthew Lewis)

Source: http://news.yahoo.com/lilly-once-weekly-diabetes-drug-proves-superior-stage-150601939.html

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Reasons That Birds Aren't Good Pets for Everybody

Why Birds Aren't As Popular As Cats and Dogs | By Alyson Kalhagen

"Can you deal with a pet that is guaranteed to bite you, defecate on you, and crave your attention in its every waking minute of the day? If not, then a bird is not the right pet for you, and you are not alone.

It takes a special kind of person to be a pet bird owner, and often, that type of person is a rare breed.?

Check out the information HERE for more reasons why bird just don't make the best pets for everybody. Knowing what it takes to live with and care for an exotic animal like a parrot is extremely important if you are considering adopting a pet in the future!"

To contrast these findings, here are some reasons why birds may be for you:

Top 10 Reasons Why a Bird Could Be the Best Choice for Your Family

Source: http://birdyrevolution.blogspot.com/2013/06/reasons-that-birds-arent-good-pets-for.html

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Samsung ATIV Tab 3 hands-on (video)

Well, we're no closer to finding out whether or not this is indeed the world's thinnest Windows 8 tablet, but we can confirm that the ATIV Tab 3 is stunningly thin. In fact, it's as svelte as its iOS and Android competitors, hitting an astounding 8.22mm. Samsung's following the design lines of its Galaxy range -- aside from the Windows button beneath the screen, obviously. At a distance you'd be hard-pressed to tell the difference between the ATIV Tab 3 and recent Galaxy Tabs. We like the unified approach here -- it should make it much easier to identify a Samsung device at first glance. Of course, that uniformity also means that the devices all feel similar too. That is to say, cheap and plasticky.

With an Intel Atom processor inside along with 2GB of RAM, It feels light and responsive. Apps launched pretty quickly, but we weren't able to really punish the CPU and the unreliable WiFi made testing the browser impossible. The 1,366 x 768, 10.1-inch screen pairs with an S-Pen that's housed in the bottom right corner, which isn't quite as useful as it is on the Note range... at least not yet. The don't-call-it-a-stylus comes with dedicated software, including improved handwriting-to-text, Easy Clipping and Air View all now working within Windows 8, not to mention S Note. The ATIV Tab 3 will be shipping in early August for $699, with a keyboard cover included. For now, we've got more impressions after the break.

Gallery: Samsung ATIV Tab 3 hands-on

Filed under: Tablets, Samsung

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Source: http://www.engadget.com/2013/06/20/samsung-ativ-tab-3-hands-on/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Most Beautiful Items: June 15 - June 21, 2013

It's the longest day of the year, so I don't really know what you're doing not being outside right now. But since you're here, take a moment to check out some of the best pieces of art, architecture, and design, we found this week.

---

Artists Are 3D-Printing a Room That Looks Like An Alien Cathedral

Who cares about plastic 3D-printed models of your head when an amazing, ornate room is being 3D printed out of sandstone? Digital Grotesque, as the project is called, looks like it was ripped from the frames of a sci-fi film.

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Hutong Vs. Highrise: A Photo Essay On China's Radical Urban Changes

Beijing is one of the earliest still-existant cities planned around a grid: the old city is organized around a chessboard-like matrix of alleys, known as hutong, that date back at least a millenium. But as developers in Beijing scramble to built modern towers in the urban core, hutong are disappearing.

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20 Photos of Iconic Buildings and Bridges As They Were Being Built

There's a great scene in the first season of Mad Men where Don unveils a campaign for Bethlehem Steel. "New York, Chicago, and Detroit?all brought to you by Bethlehem," reads the copy. The client rejects the pitch, but the sentiment itself was hard to argue with: steel from those small rustbelt towns was feeding the?

---

Ask a New York City Movie Location Scout Anything You Want

Did you know there's an abandoned swimming pool in the basement of the Woolworth Building? Did you know there's an abandoned Cold War-era missile silo buried under a log cabin in the Adirondacks? Do you have any idea what happened with the filming location ofGhostbusters or Annie Hall? Nope! But Nick Carr, the?

---

This Soaring Openair Cafe Is Made From Giant Bamboo Fishing Baskets

In Vietnam, it's common to use bamboo baskets to catch fish and eels. Less common? To find the same type of bamboo structures supporting an entire building. This open-air beauty is the Kontum Indochine Cafe, in central Vietnam, and it looks like it's supported by 15 giant bamboo fishing baskets.

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Unlock NYC's Architectural Gems With This Foursquare Scavenger Hunt

New Yorkers rarely have time to stop and look up at the city around them, but the Museum of Modern Art is pushing us to do just that with a city-wide scavenger hunt that challenges players to explore the city's architectural landmarks.

---

23 Lighthouses That Span a Millennium of Sea Travel

For most of us, lighthouses are synonymous with trips to the shore. But for seafarers, lighthouses have represented a vital symbol of safe passage for centuries. In fact, they go back to 280 BC, when the famed Lighthouse of Alexandria was built?though lighthouses of the ancient world looked more like battlements than?

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London's Triangular "Cheesegrater" Tower Rises In This Gorgeous Video

British architect Richard Rogers is known for putting the guts of buildings on display. In fact, his work has even inspired the scatological style known as Bowellism. This summer, Rogers' exoskeletal style is being writ large in London, where he's building a wedge-shaped tower called the Leadenhall Building. And lucky ?

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A Space-Inspired Floating Playground That Puts Visitors Into Orbit

Tom?s Saraceno's M.O. as an artist is to make you float?either on top of millions of yards of plastic, or inside of hexagonal sky pods, or on top of an inflatable balloons. His latest Jules Verne-tinged installation, which opened today, is no different.

---

We Are Light-Eaters: The Unearthly Art of James Turrell

The last time James Turrell staged a major installation in a New York museum, lawsuits ensued: two visitors, who ostensibly didn?t realize what they were in for, sued Turrell after they became disoriented and fell inside of an installation in 1980. Thankfully, that hasn't stopped Turrell manipulating our senses?in?

Source: http://gizmodo.com/most-beautiful-items-june-15-june-21-2013-534961924

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Heat Repeat Champions: Big Three Leads Miami to 2nd Straight NBA Title (VIDEO/PHOTOS)

MIAMI (AP) ? LeBron James will always remember his first championship. History will remember this one.

The way the Heat won ? or the way James wouldn't let them lose ? makes them one of the greats.

A Game 6 comeback when it appeared to be over, then a stirring Game 7 victory over a proud opponent cemented a place with the NBA's giants for this Miami team and its leader.

"Last year when I was sitting up here with my first championship, I said it was the toughest thing I had ever done," James said. "This year, I'll tell last year he's absolutely wrong. This was the toughest championship right here between the two."

And the San Antonio Spurs will always know it's a title they let slip away.

James scored 37 points and grabbed 12 rebounds in a 95-88 victory Thursday night in a tense game that was tight until Miami pulled away in the final minute.

Capping their best season in franchise history ? and perhaps the three-superstar system they used to build it ? the Heat ran off with the second straight thriller in the NBA's first championship series to go the distance since 2010.

Two nights after his Game 6 save when the Heat were almost eliminated, James continued his unparalleled run through the basketball world, with two titles and an Olympic gold medal in the last 12 months.

"I work on my game a lot throughout the offseason," said James, who was MVP for the second straight finals. "I put a lot of work into it and to be able to come out here and (have) the results happen out on the floor is the ultimate. The ultimate. I'm at a loss for words."

He made five 3-pointers, defended Tony Parker when he had to, and did everything else that could ever be expected from the best player in the game.

The Heat became the NBA's first repeat champions since the Lakers in 2009-10, and the first team to beat the Spurs in the NBA Finals.

"It took everything we had as a team," Dwyane Wade said. "Credit to the San Antonio Spurs, they're an unbelievable team, an unbelievable franchise. This is the hardest series we ever had to play. But we're a resilient team and we did whatever it took."

Players and coaches hugged afterward ? their respect for each other was obvious from the opening tipoff of Game 1 through the final buzzer.

A whisker away from a fifth title two nights earlier, the Spurs couldn't find a way to win it all in what was perhaps the last shot for Tim Duncan, Parker and Manu Ginobili to grab another ring together.

"In my case I still have Game 6 in my head," Ginobili said. "Today we played an OK game, they just made more shots than us. LeBron got hot. Shane (Battier), too. Those things can happen. But being so close and feeling that you are about to grab that trophy, and seeing it vanish is very hard."

They were trying to become the first team to win a Game 7 on the road since Washington beat Seattle in 1978, but those old guys ran out of gas just before the finish.

Fans stood, clapped and danced as the clock ticked down, when every score was answered by another score, each stop followed by a better stop. The Heat pushed their lead to six points a few times midway through the fourth but San Antonio kept coming back.

Duncan had 24 points and 12 rebounds for the Spurs, but missed a shot and follow attempt right under the basket with about 50 seconds left and the Spurs trailing by two.

James followed with a jumper ? the shot the Spurs were daring him to take earlier in the series ? to make it 92-88, sending San Antonio to a timeout as Glenn Frey's "The Heat Is On" blared over the arena's sound system.

He then came up with a steal and made two free throws for a six-point lead, and after Ginobili missed, James stalked toward the sideline, knowing it was over and that he was, once again, the last one standing.

Wade had 23 points and 10 rebounds for the Heat, who overcame a scoreless Chris Bosh by getting six 3-pointers and 18 points from Battier.

"It was a great series and we all felt that," Spurs coach Gregg Popovich said. "I don't know if 'enjoy' is the right word, but in all honesty, even in defeat, I'm starting to enjoy what our group accomplished already, when you look back. And you need to do that, to put it in perspective. So it's no fun to lose, but we lost to a better team.

"And you can live with that as long as you've given your best, and I think we have."

Streamers fell from the arena ceiling onto the fans for the second year in a row, but this one meant so much more. A narrow escape in Game 6 was still fresh in everyone's mind.

They were down 10 in the fourth quarter of that one before James led the charge back, finishing with a triple-double in Miami's 103-100 overtime victory. This one was nearly as tight, neither team leading by more than seven and the game tied 11 times.

Kawhi Leonard had 19 points and 16 rebounds for the Spurs, who had been 4 for 4 in the championship round. Ginobili had 18 points but Parker managed just 10 points on 3-of-12 shooting.

"Just give credit to the Miami Heat. LeBron was unbelievable. Dwyane was great. I just think they found a way to get it done," Duncan said. "We stayed in the game. We gave ourselves opportunities to win the game, we just couldn't turn that corner."

The Heat and coach Erik Spoelstra collected the Larry O'Brien trophy again from Commissioner David Stern, presiding over his last NBA Finals before retiring next February.

He couldn't have asked for a better way to go out.

James avenged his first finals loss, when his Cleveland Cavaliers were swept by the Spurs on 2007. That helped send James on his way to South Florida, realizing it would take more help to win titles that could never come alone.

He said he would appreciate this one more because of how tough it was. The Heat overpowered Oklahoma City in five games last year, a team of 20-something kids who weren't ready to be champions yet.

This came against a respected group of Spurs whose trio has combined for more than 100 playoff victories together and wanted one more in case this was San Antonio's last rodeo.

Duncan is 37 and Ginobili will be a 36-year-old free agent next month, the core of a franchise whose best days may be behind them.

Meanwhile, it's a potential dynasty along Biscayne Bay, but also one with a potentially small window. Wade's latest knee problems are a reminder that though he came into the NBA at the same time as James and Bosh 10 years ago, he's a couple of years older at 31 with wheels that have seen some miles.

James can become a free agent again next summer with another decision ? though hopefully not another "Decision" ? to make. He's comfortable in Miami and close with Wade, and the Heat have the leadership and commitment from owner Micky Arison and president Pat Riley to keep building a championship core around him.

Why would he want to leave?

"This team is amazing," James said. "And the vision that I had when I decided to come here is all coming true."

Notes: Home teams are 15-3 in Game 7s of the NBA Finals. ... Miami improved to 5-3 all-time in Game 7s in the postseason and became the fourth team to win the final two games at home since the finals went to a 2-3-2 format in 1985, joining the Lakers in 1988 and 2010, and Houston Rockets in 1994. ... Green was just 1 for 12, going 1 for 6 behind the arc. He started the series by making 25 3s in the first five games, a finals record for an entire series.

___

Follow Brian Mahoney on Twitter: http://www.twitter.com/Briancmahoney

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Source: http://www.huffingtonpost.com/2013/06/21/miami-heat-repeat-champions-big-three_n_3476654.html

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Light and nanoprobes detect early signs of infection

June 20, 2013 ? Duke University biomedical engineers and genome researchers have developed a proof-of-principle approach using light to detect infections before patients show symptoms.

The approach was demonstrated in human samples, and researchers are now developing the technique for placement on a chip, which could provide fast, simple and reliable information about a patient. A diagnostic device based on this chip also could be made portable.

The researchers developed a silver-based nanoparticle that homes in on a specific molecular marker that spills into the bloodstream at the first stages of an infection. When light is aimed at the sample, the nanoparticle attached to a molecular marker will reflect a distinct optical fingerprint.

"We have demonstrated for the first time that the use of these nanoprobes can detect specific genetic materials taken from human samples," said Tuan Vo-Dinh, the R. Eugene and Susie E. Goodson Distinguished Professor of Biomedical Engineering at Duke' Pratt School of Engineering and director of The Fitzpatrick Institute for Photonics at Duke. He is also a professor of chemistry.

The results of the Duke experiments appear online in the journal Analytica Chimica Acta. Hsin-Neng Wang, a post-doctoral fellow in Vo-Dinh's laboratory, was the first author of the paper.

In this interdisciplinary project, the Vo-Dinh team collaborated closely with scientists at Duke's Institute for Genome Sciences & Policy (IGSP) who have developed a method of measuring the host's response to infection through RNA profiling.

The research is supported by the National Institutes of Health, the Defense Advanced Projects Agency, the Department of Defense and the Wallace H. Coulter Foundation.

In the Duke experiments, the nanoprobes are used in conjunction with a phenomenon first described in the 1970s known as surface-enhanced Raman scattering (SERS). When light, usually from a laser, is shined on a sample, the target molecule vibrates and scatters back in its own unique light, often referred to as the Raman scatter. However, this Raman response is extremely weak.

"When the target molecule is coupled with a metal nanoparticle or nanostructure, the Raman response is greatly enhanced by the SERS effect -- often by more than a million times," said Vo-Dinh, who has been studying the potential applications of SERS for decades.

"This important proof-of-concept study now paves the way for the development of devices that measure multiple genome-derived markers that will assist with more accurate and rapid diagnosis of infectious disease at the point of care," said Geoffrey Ginsburg, director of genomic medicine at the IGSP, executive director of the Center for Personalized Medicine at Duke Medicine, and a professor of medicine and pathology.

"This would guide care decisions that will lead to more effective treatment and improved outcomes of antimicrobial therapy," Ginsburg said. "Point-of-care diagnostics holds great promise to accelerate precision medicine and, more importantly, help patients in limited-resource settings gain access to molecular testing."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/bB4VZQVAqos/130620162846.htm

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Zeebox can now listen in, automatically identify what you're watching

Zeebox is making good on its cooperation with Gracenote today with the announcement that the second screen app can now automatically identify what you're watching through analysis of the show's "audio fingerprint." Several second screen TV apps use similar technology to sync up with what's on TV, although this implementation is more closely matched to what we've seen from IntoNow. Naturally, use of the latest feature is entirely optional, which includes the ability to automatically listen in when you start the app, along the with ability to manually activate the function by tapping a microphone icon. Gracenote reps tell us that Zeebox records a short, Vine-length audio clip, and then generates an audio profile based on that, which is recognized by Gracenote's Entourage system -- the audio recording itself never leaves your device. The new functionality is available on all versions of Zeebox, which includes Android, BlackBerry and iOS, but the ability for Gracenote to automatically identify shows is limited to programs that've aired in the past seven days.

Filed under: Home Entertainment, Software, HD

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Source: Zeebox (App Store), Google Play, BlackBerry World

Source: http://www.engadget.com/2013/06/20/zeebox-is-listening/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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[pics] Samsung To Livestream Its Galaxy And Ativ 'premiere' Event

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Murkowski becomes third Republican U.S. senator to back gay marriage (reuters)

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Savvy Money: When you get a new job, don't forget to do something ...

By Christina Harrison and Judy Howell
KyForward columnists
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You?ve just started a new job and are immersing yourself in your newly assigned responsibilities. Then you get it in the mail ? a 401(k) statement from your previous employer. ?What should I do with this?? you wonder. If the answer is to file it and forget it, you might want to think again.
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Your options for an ?old? 401(k) are fairly limited. You can leave it where it is, roll it into an IRA, or move it to your new employer?s plan (if the new plan allows it). Let?s look at those options a little more closely.
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1. Leave it where it is. Most plans will allow you to leave the funds there, with one glaring exception, explained below.
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If your old plan will allow you to leave it there, why would you want to do so? The two things to be evaluated: total costs and investment options. Does the old plan offer a good range of investment options ? preferably institutional shares of great mutual funds? Does it offer a stable value fund which yields more than traditional money market funds? Are there other administrative costs associated with this plan?
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If the old plan meets those criteria, then you will want to leave your money in the old 401(k) as is. Also, 401(k) plans typically offer better protection from legal threats than IRAs.
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Now, what is the exception? If your balance is below $5,000, the old plan has the right to remove your money from the plan. Small account balances tend to cost the 401(k) plan more, so employers have the option to force you to move your money.
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The plan will notify you at that time, so you have the opportunity to either roll it into a new IRA or into your current employer?s 401(k) plan. They will send you paperwork that allows you to process a direct rollover.
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If you do not respond, the old 401(k) plan can either roll your money into an IRA that will probably have a default investment. If they send the money out to you, they will send 20 percent to Uncle Sam first. And you will pay income tax and penalties on that distribution.
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There is a way around that if you find yourself in that position ? you can take the check you receive and roll it over to an IRA . If you can, add your own money to the deposit to make your rollover amount equal to the distribution amount. That way the whole distribution is tax-deferred, and you will receive credit on the tax withholding when you file your Federal income tax. You MUST complete the rollover within 60 days of the distribution.
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If your old 401(k) balance is less than $1,000, your old employer may simply cash you out, withhold 20 percent and send you a check. You can still follow the instructions above to roll it into an IRA, making up the tax withholding with your own dollars. Again, that means the distribution, as long as done within 60 days, will not be taxable to you.
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2. Roll the complete balance into an IRA. When you terminate employment, you should receive paperwork containing instructions on how to roll your plan amount into an IRA of your choice. Once you get the paperwork done (it can be a little overwhelming, because the old 401(k) sends you so much paperwork, but it?s really not hard), the old 401(k) plan sends the funds directly to your new IRA. Voila! It is done without any income tax implications and no extra work on your part.
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The best news in rolling the IRA over to a self-directed IRA is that you have more investment options. If you want to roll the funds over to a particular fund family, then you are limited by its offerings. You have the option to transfer the old funds to a brokerage IRA which would allow you a much wider range of mutual fund options and the opportunity to purchase individual bonds (as opposed to a bond fund which may lose value as interest rates rise).
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3. Roll the complete balance into your new employer?s plan. You will first need to confirm that the new 401(k) allows rollovers. Once you have confirmed that the new plan will accept your old funds and have evaluated the new plan (see No. 1), you can roll the funds over to your new plan. The nice thing about this option is it does cut down on the number of statements you will receive and allows you to see your combined retirement assets in one place.
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The bottom line to all of the above is: Be sure to do SOMETHING with your old 401(K) funds.
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If you have $1,000 in an old 401(k) and let the plan send you a check less taxes, you will receive somewhere around $550 (depending on your tax bracket). If you are able to invest it and earn 5 percent a year for 30 years, it will become $4,321. In 30 years, you probably won?t remember where you spent the $550, but you will be glad to have $4,300.
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Christina Harrison and Judy Howell, H2 Investments, are affiliated with First Kentucky Securities Corporation (member FINRA, SIPC). They have over 25 years of experience assisting individuals in meeting their investment and retirement goals.

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Source: http://www.kyforward.com/our-business/2013/06/18/savvy-money-when-you-get-a-new-job-dont-forget-to-do-something-with-your-old-401k/

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CA-NEWS Summary

Obama says will meet oversight board about NSA surveillance

WASHINGTON (Reuters) - President Barack Obama said on Monday he will meet soon with a privacy and civil liberties oversight board to discuss ways to balance the need for U.S. surveillance while respecting people's right to privacy. Obama, in an interview with PBS anchor Charlie Rose, said he believed there is plenty of transparency about the U.S. government's top-secret monitoring of Americans' phone and Internet data but that he has asked the intelligence community to see if there is more that can be revealed about it to reassure people.

Putin faces isolation over Syria as G8 ratchets up pressure

ENNISKILLEN, Northern Ireland (Reuters) - Russian President Vladimir Putin faced further isolation on the second day of a G8 summit on Tuesday as world leaders lined up to pressure him into toning down his support for Syrian President Bashar al-Assad. Following an icy encounter between the Kremlin chief and U.S. President Barack Obama late on Monday, the G8 leaders will seek to find resolution to a war that has prompted powers across the Middle East to square off on sectarian lines.

Explosion in Kabul coincides with Afghan security handover

KABUL (Reuters) - A bomb targeted a senior Shia Muslim cleric in the west of Kabul on Tuesday, police said, shortly before the international military coalition marked its final handover of security to national forces. At least three civilians were killed and 21 wounded in the blast, which is bound to fuel concern over how the 352,000-strong Afghan security forces will tackle an intensifying insurgency after most foreign combat troops leave the country by the end of 2014.

FBI rushes to Newark airport after passenger says poison on plane

NEWARK, New Jersey (Reuters) - A passenger who screamed that he had poison aboard a plane that was headed for New Jersey's Newark airport on Monday was taken into custody by FBI agents when the plane landed, law enforcement officials said. United Airlines Flight 116 was en route from Hong Kong to Newark Liberty International Airport when a passenger "became disruptive," the carrier said.

Lawyer Cliff Sloan faces tough assignment: Closing Guantanamo

WASHINGTON (Reuters) - Cliff Sloan has represented Jon Bon Jovi's band in legal matters and argued cases before the U.S. Supreme Court. Now, he has perhaps his toughest assignment: Helping to close the U.S. military prison at Guantanamo Bay, Cuba. The Washington attorney was named on Monday as the State Department's Guantanamo Bay envoy, a central player in President Barack Obama's renewed push to make good on a 2008 campaign promise to shut the installation where the United States holds terrorism suspects. Obama wants to close the facility because it is a legacy of the Bush administration that he feels has damaged the U.S. reputation with allies around the world.

Turkey could deploy army to quell protests

ANKARA/ISTANBUL (Reuters) - Turkey's deputy prime minister said on Monday the armed forces could be called up if needed to help quell popular protests that have swept Turkish cities in the last two weeks, the first time the possibility of a military role has been raised. Bulent Arinc made the remarks in Ankara, where 1,000 striking trade union workers faced off briefly against police backed by several water cannon, before police retreated and the crowd left.

U.S. right to arm Syrian rebels, says Israeli president

JERUSALEM (Reuters) - Israeli President Shimon Peres has thrown his weight behind U.S. plans to arm Syrian rebels, shrugging off fears the weapons could be turned on Israel and exacerbate the conflict. In a wide-ranging interview with Reuters before his 90th birthday, Peres dismissed the idea that Israel could launch a unilateral military strike against Iran's nuclear facilities and urged Palestinians and Israelis to forge immediate peace.

Snowden hits back against critics of NSA leaks

WASHINGTON (Reuters) - The former National Security Agency contractor who revealed the U.S. government's top-secret monitoring of Americans' phone and Internet data fought back against his critics on Monday, saying the government's "litany of lies" about the programs compelled him to act. Edward Snowden told an online forum run by Britain's Guardian newspaper that he considered it an honor to be called a traitor by people like former Vice President Dick Cheney, and he urged President Barack Obama to "return to sanity" and roll back the surveillance effort.

Obama sees Iran's election of moderate as hopeful sign

WASHINGTON (Reuters) - President Barack Obama said on Monday that Iran's election of a moderate as its next president is a sign that Iranians want to move in a different direction, but he was uncertain whether it would lead to a breakthrough over Tehran's nuclear ambitions. In an interview with public television anchor Charlie Rose, Obama said the United States and its allies would be willing to hold talks with Iran over its nuclear program, as long as Tehran recognized that international sanctions would not be lifted unless Iran proved it is not building a nuclear weapon.

Putin, Obama face off over Syria; rebels get Saudi missiles

ENISKILLEN, Northern Ireland/DUBAI (Reuters) - Rebels fought to halt an advance by President Bashar al-Assad's forces into northern Syria on Monday while U.S. President Barack Obama faced a showdown with Russia's Vladimir Putin over Obama's decision last week to arm the insurgents. New evidence emerged of escalating foreign support for the rebels, with a Gulf source telling Reuters that Saudi Arabia had equipped fighters for the first time with shoulder-fired anti-aircraft missiles, their most urgent request. Rebels said Riyadh had also sent them anti-tank missiles.

Source: http://news.yahoo.com/ca-news-summary-000524607.html

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How useful is fracking anyway? Study explores return of investment

June 17, 2013 ? The value of a fuel's long-term usefulness and viability is judged through its energy return on investment; the comparison between the eventual fuel and the energy invested to create it. The energy return on investment (EROI) study published in the Journal of Industrial Ecology finds that shale gas has a return value which is close to coal.

In the United States, gas is mined from horizontal, hydraulically fractured wells in the Marcellus Shale of Pennsylvania. The study compares the total input energy with the energy expected to be made available to end users.

The analysis indicates that the EROI ratio of a typical well is likely between 64:1 and 112:1, with a mean of approximately 85:1. This range assumes an estimated ultimate recovery (EUR) of 3.0 billion cubic feet per well. This is similar to the EUR of coal, which falls between 50:1 and 85:1.

"Our analysis indicates that gas can be extracted from shale efficiently, from an energy perspective. The energy return on (energy) investment ratio (EROI) does seem to be at least as favorable as coal," said lead author Mike Aucott. "However, a comparison with coal is difficult. There appear to be large amounts of coal still available. Estimates of the amount of gas available from the shale plays vary widely. It is not clear yet whether there is anywhere near enough to rival coal over the long haul."

"There are concerns about water pollution and other environmental impacts associated with shale gas production," concluded Aucott. "With the assumption that these can be managed, and that production quantities remain consistent with initial production data, the favorable EROI suggests that shale gas will be a viable energy source for quite some time."

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Story Source:

The above story is reprinted from materials provided by Wiley, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Michael L. Aucott, Jacqueline M. Melillo. A Preliminary Energy Return on Investment Analysis of Natural Gas from the Marcellus Shale. Journal of Industrial Ecology, 2013; DOI: 10.1111/jiec.12040

Note: If no author is given, the source is cited instead.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/5etzlbw5poQ/130617111355.htm

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West rebukes Putin over Syria at G8 summit

By Roberta Rampton and Alexei Anishchuk

ENNISKILLEN, Northern Ireland (Reuters) - Western leaders rebuked Russian President Vladimir Putin for supporting Syria's Bashar al-Assad's attempt to crush a two-year-old uprising, setting the stage for a tense G8 summit of the world's most powerful nations.

U.S. President Barack Obama is expected to use his first face-to-face meeting with Putin in a year to try to persuade the Kremlin chief to bring Assad to the negotiating table to end a conflict in which at least 93,000 people have been killed.

British Prime Minister David Cameron, who is chairing the G8 summit in a remote golf resort in Northern Ireland, conceded there was "a big difference" between the positions of Russia and the West on how to resolve the war.

In some of his most colorful remarks on Syria, Putin described anti-Assad rebels as cannibals who ate human flesh and warned Obama of the dangers of giving guns to such people. Moscow also said it would not permit no-fly zones over to Syria.

For their part, Western leaders have criticized Russia, Syria's most powerful ally, for sending weapons to Assad forces and considering deliveries of a sophisticated missile system.

"How can we allow that Russia continues to deliver arms to the Bashar al-Assad regime when the opposition receives very few and is being massacred?" French President Francois Hollande said.

Stung by recent victories for Assad's forces and their support from Hezbollah guerrillas, the United States said last week it would step up military aid to the rebels including automatic weapons, light mortars and rocket-propelled grenades.

In an apparent response to this development, Assad said Europe would "pay the price" if it delivered arms to rebel forces, saying that would result in the export of terrorism to Europe.

"Terrorists will gain experience in combat and return with extremist ideologies," he said in an advance extract of an interview due to be published in the Frankfurter Allgemeine Zeitung on Tuesday.

Divisions over Syria dominated the atmosphere as global leaders streamed into the heavily guarded resort in Northern Ireland, a place once rocked by decades of violence but which Cameron now wants to showcase as a model of conflict resolution.

Despite the disagreements over Syria, Putin and his Western counterparts appeared cordial in their public appearances. The Kremlin chief cracked a grin as he shook Cameron's hand outside the venue, as police helicopters surveyed the site overhead.

Moscow and Washington both agree that the bloodshed in Syria should stop and say they are genuinely trying to overcome mistrust between them. They had earlier agreed to set up a Syrian peace conference in Geneva but progress has been slow.

The European Union has dropped its arms embargo on Syria, allowing France and Britain to arm the rebels, though Cameron expressed concern about some of Assad's foes.

"Let's be clear - I am as worried as anybody else about elements of the Syrian opposition, who are extremists, who support terrorism and who are a great danger to our world," Cameron said.

Syria aside, Cameron wants to focus on the formal agenda on tax, trade and transparency, dubbed "The Three Ts", topics expected to dominate discussions on Tuesday.

As the summit kicked off on Monday afternoon, the United States and the EU opened negotiations for the world's most ambitious free-trade deal, promising thousands of new jobs and accelerated growth on both sides of the Atlantic.

OBAMA-PUTIN TALKS

The spotlight was on Obama and Putin who were due to meet at about 6:30 p.m. (1730 GMT) at the Lough Erne golf resort about 10 km (7 miles) outside the Northern Irish town of Enniskillen, scene of an IRA bomb attack in 1987 that killed 11 people.

Security was tight and the venue was surrounded by a 15-ft high steel fence. Unlike previous summits which have seen often turbulent anti-capitalist protests, the meeting failed to attract any crowds, possibly due to its remote location.

In a speech in Belfast, Obama urged young people in Northern Ireland to finish making "permanent peace" and set an example to other areas of the world stricken by conflict.

Cameron could also face some awkward questions at the G8 table after a Guardian newspaper report that Britain spied on officials taking part in two Group of 20 meetings in 2009.

In a report published just hours before the G8 summit, the daily said some delegates from countries in the Group of 20 - which comprises top economies around the world - used Internet cafes that had been set up by British intelligence agencies to read their emails.

"If these allegations prove to be true, it will be condemned in the strongest fashion and the necessary action taken," said Turkish Finance Minister Mehmet Simsek, who the Guardian said had his calls intercepted by Britain.

The leaders of the United States, Japan, Canada, Russia, Germany, France, Britain and Italy - representing just over half of the $71.7 trillion global economy - will also discuss global economy and trade.

Japanese Prime Minister Shinzo Abe, German Chancellor Angela Merkel and other leaders are likely to say they are not content with progress so far in fixing their economies in the wake of the global financial crisis, according to a draft communiqu? seen by Reuters.

Abe will use the opportunity to explain his blend of fiscal and monetary stimuli known as 'Abenomics' to the leaders as investors try to absorb the implications of a signal by the U.S. Federal Reserve it may start to slow its money-printing.

(Additional reporting by Maria Golovnina, William Schomberg, Andrew Osborn, Kate Holton, Jeff Mason and Gernot Heller in Enniskillen, Gabriela Baczynska in Moscow; Writing by Guy Faulconbridge and Maria Golovnina)

Source: http://news.yahoo.com/obama-putin-face-tough-talks-syria-g8-summit-072959981.html

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Supreme Court strikes down Arizona voting law (cbsnews)

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Yankees, Rivera survive wild 9th to snap skid

ANAHEIM, Calif. (AP) ? Bases loaded with two outs. Bottom of the ninth inning in a one-run game. The greatest closer in baseball history facing one of the best hitters of his generation.

An average Sunday afternoon game swiftly turned into a memorable moment, and Mariano Rivera made it even better for the Yankees when he struck out Albert Pujols to close out New York's skid-snapping win.

Rivera fanned Pujols on three pitches to end the Angels' five-run rally in the ninth, and the Yankees stopped their five-game losing streak with a wild 6-5 victory over Los Angeles.

"The moment doesn't really get to him," Travis Hafner said of Rivera, baseball's career saves leader. "As long as he's got the lead, you feel he's going to find a way to get the win."

Rivera would have enjoyed his 632nd save a bit more if he hadn't caused much of the drama himself in the park where he made his major league debut in 1995 and earned his first save a year later.

CC Sabathia pitched five-hit ball into the ninth and Hafner hit a three-run homer off Jered Weaver, but the Yankees barely got enough from Rivera. New York's famed closer gave up three hits and a walk, but still got his 24th save in dramatic fashion.

"That's what everybody comes and pays for," said Lyle Overbay, who had an RBI double. "That was a little closer than we thought, but I didn't sense a lot of panic."

Jayson Nix also drove in a run during a five-run third inning for the Yankees, who salvaged the finale of their 10-game road trip by battering Weaver (1-3) early and hanging on by their fingernails late.

Sabathia (7-5) struck out six and walked three, but tired in the ninth, leaving with two runners on. After reliever David Robertson left with a 6-1 lead, Rivera gave up Erick Aybar's RBI groundout, Alberto Callaspo's two-run single and Peter Bourjos' RBI single.

Rivera then walked Mike Trout to load the bases before getting Pujols.

"That was a great rally and a lot of fun to be a part of," said Mark Trumbo, who drove in the Angels' first run in the ninth. "You know the odds are heavily stacked against you, especially with a guy like CC out there. That's exactly what we wanted to see. It was very, very close, and that's about all you can hope for against a guy like Mariano Rivera. Maybe one more blooped (hit) and we win this ballgame."

Former Angels outfielder Vernon Wells drove in what turned out to be the decisive run with a sacrifice fly off Jerome Williams in the eighth.

Despite the finish, Sabathia decisively won the matchup of both clubs' top starters. Weaver gave up seven hits and four walks over six innings for the Angels, who had won three straight.

Los Angeles managed just four singles off Sabathia until the crazy ninth.

Sabathia left after Trout's leadoff double and a walk to Pujols. Trumbo then got an RBI with a line drive that hit Robertson and bounced into right field for a single. Robertson stayed in the game, but loaded the bases with a one-out walk to pinch-hitter J.B. Shuck.

That created an unlikely save opportunity with a five-run lead for Rivera, but the 43-year-old wasn't sharp. Aybar and Callaspo drove in runs before pinch-hitter Brad Hawpe delivered his first major league hit in two years.

Bourjos then singled home Callaspo to trim New York's lead to one run. Trout drew a walk to load the bases for Pujols, but the Angels' $240 million man couldn't connect.

"We really executed well in the ninth inning and had some good at-bats," Angels manager Mike Scioscia said. "There was some good situational hitting and some guys off the bench did a good job. Unfortunately, we couldn't get that tying run across. Rivera made some tough pitches to Albert at the end and closed the door, but our guys were upbeat the whole game."

New York is without injured regulars Derek Jeter, Alex Rodriguez, Mark Teixeira, Curtis Granderson and Kevin Youkilis, but got offense from less likely sources in the series finale. Nix had three hits, while Hafner's two-out shot ended his 0-for-23 skid for the Yankees, who hadn't scored more than four runs in eight straight games before doing it in the third inning alone at Angel Stadium.

Weaver struck out six, but repeatedly found trouble in his fourth start since returning from a 45-game stint on the disabled list. A 20-game winner last season, the Angels' longtime ace is winless in his last three starts.

Weaver had two outs and two strikes on Hafner before the veteran hit his 11th homer. Hafner had just five hits in his previous 53 at-bats before connecting against Weaver, including a 2-for-27 start to the road trip.

"I didn't really accomplish anything that I try to accomplish through the course of a game," Weaver said. "Walks were bad, first-pitch strikes were bad, and I obviously didn't get deep in the game. It's just one of those games where I found myself battling the whole game."

NOTES: Teixeira got a cortisone shot in his injured right wrist and will be re-evaluated next week, but manager Joe Girardi said the tendon sheath around his wrist is just inflamed, not torn again. Teixeira left Saturday's game in the fourth inning and returned to New York for examination on his wrist, which kept him out for the first 53 games of the season. ... Ichiro Suzuki stole another base, giving him three steals in two games. The Japanese star had just six stolen bases all season before the weekend. ... Josh Hamilton got a day off for the Angels, not even pinch-hitting in the ninth.

Source: http://news.yahoo.com/yankees-rivera-survive-wild-9th-snap-skid-224930152.html

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